It would be an oversimplification to state that the cannabinoids follow a specific mechanism or method for networking with the ECS which leads to health benefits. Apparently, it seems that the cannabinoids simply acts upon your endocannabinoid system to offer you relief from pain, insomnia, and hypertension. But scientists are strongly of the opinion that there is more to it than meets the eye-the interrelation of cannabinoids with ECS’s receptors is remarkably complex.
The researchers and scientists have indicated that the plant compounds (cannabidiol) not only influences the ECS but also other physiological systems of the body. Studies and researches have pointed out that understanding CBD’s direct impact on the ECS’s receptors can be remarkably challenging. You’ll be quite surprised to learn that CBD does not find endocannabinoid receptors very enticing, and therefore has a low appetite for them.
By the same token, for the endocannabinoid receptors CBD is not their top priority when it comes to interacting with external phytochemicals. The receptors have a far greater affinity for the intrinsic anandamide-a fatty acid neurotransmitter- which is the equivalent of CBG, the popular psychoactive compound of cannabis. There is a widely held belief that as far as the CB1 receptor was concerned, it did not find the CBD to be attractive enough for binding to it.
Additionally, CBD’s tethering with the CB1 receptor was very different from that of the CB2 receptor. At the same time, the CB 1 receptor got attached to CBD in a somewhat different site. The scientists discovered that CBD happened to be a robust negative allosteric modulator of the CB 1receptor.
The unconstructive allosteric modulating effects of CBD on CB 1 receptor can be best studied when CBG is present. Hitherto scientists believed that CBD had a dulling effect on CBG-greatly alleviating its psychoactive potential. With passage of time, the researchers were able to effectively prove that the manner in which CBG interacted with the CB1 receptor diminished its psychotropic capacity.
The other prominent endocannabinoid receptor-CB 2 plays a key role in causing inflammation. When it comes to the CB 2 receptor’s working mechanism, it has an effect on CBD and CBG that is in sharp contrast to CB 1 receptor’s action. The CBG works as a stimulant and activates the CB 2 receptor while the CBD reduces its efficacy. This mechanism or procedure is largely responsible for the CBD’s anti-inflammatory properties. However, it should be noted that cannabidiol being a feeble inverse agonist of CB 2 has a minimal effect on the receptor.
So, how do you explain the beneficial effects of cannabidiol in the light of the fact that CBD has an indirect effect on one receptor while hardly interacting with the other? The answer is that the positive effects of CBD arise from its capability to influence the endocannabinoid system (even if it is indirect) and also from its capacity to manipulate and affect a host of other physiological systems.
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Source: https://vidya-life.com/why-cbd-works
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